In vitro

Lee CL, Jiang PP, Sit WH, Wan JM. Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: analysis of significant proteins that manipulate T cells proliferation and immunosuppression. Int Immunopharmacol. 7(10): 1311-24 (2007). Abstract

2006

In vitro & animal

Chan, S.L. et al. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem. Toxicol.44, 689-694 (2006). *** Abstract

In vitro

Wu, J.M. et al. Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP). BMC Complement. Altern. Med. 6, 30 (2006). *** Full PDF Article

Hsieh TC and Wu JM. Differential control of growth, cell cycle progression, and gene expression in human estrogen receptor positive MCF-7 breast cancer cells by extracts derived from polysaccharopeptide I'm-Yunity and Danshen and their combination. Intern J Oncol.29, 1215-1222 (2006). Abstract

2005

Clinical (Human)

Wong, C.K., et al. Immunomodulatory activities of Yunzhi and Danshen in post-treatment breast cancer patients. Am. J. Chin. Med.33, 381-395 (2005). *** Abstract

In vitro

	Zeng, F. et al. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 using cDNA microarray. Int. J. Oncol.27, 513-523 (2005). *** Abstract
	Hui, K.P. et al. Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells. Oncol. Rep.14, 145-155 (2005). *** Abstract
	Yang X. et al. The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells. Oncol. Rep.13, 1201-1210 (2005).*** Abstract
	Ho, C.Y. et al. Differential anti-tumor activity of coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells. Cancer Biol. Ther.4, 638-644 (2005). Abstract
	Coles, M. et al. Lack of prevention of large intestinal cancer by VPS, an extract of Coriolus versicolor mushroom. In vivo.19, 867-871 (2005). Abstract

2004

Clinical (Human)

Wong, C.K. et al. Immunomodulatory effects of yun zhi and danshen capsules in health subjects - a randomized, double-blind, placebo-controlled, crossover study. Int. Immunopharmacol.4, 201-211 (2004). *** Abstract

In vitro

	Ho, C.Y. et al. Differential effect of Coriolus versicolor (Yunzhi) extracts on cytokines production by murine lymphocytes in vitro. Int. Immunopharmacol.4, 1549-1557 (2004). Abstract
	Ho, J.C. et al. Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice. Life Sci.75, 1343-1356 (2004). Abstract
	Lau, C.B. et al. Cytotoxic activities of Coriolus versicolor (Yunzhi) extracts on human leukemia and lymphoma cells by induction of apoptosis. Life Sci.75, 797-808 (2004). Abstract

2003

Clinical (Human)

Tsang, K.W. et al. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Resp. Med.97, 618-624 (2003). Reprint is available upon request by email. *** Abstract

Review

	Monro, J.A. Treatment of cancer with mushroom products. Arch. Environ. Health58, 533-537 (2003). Abstract
	Cui, J. et al. Polysaccharopeptide of coriolus versicolor: physiological activity, uses, and production. Biotechnol. Adv.21, 109-122 (2003). Abstract

2002

Animal

Song, L.C. et al. Effects of coriolus versicolor polysaccharide B on monocyte chemoattractant protein 1 gene expression in rat. Acta Pharmacol. Sin.23, 539-543 (2002). Abstract

In vitro

	Hsieh, T.C. et al. Effects of extracts of Coriolus versicolor (I’m Yunity) on cell-cycle progression and expression of Interleukins-1β, -6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes. J. Altern. Complem. Med.8, 591-602 (2002). Reprint is available upon request by email. *** Abstract
	Mau, J.L. et al. Antioxidant properties of several medicinal mushrooms. J. Agric. Food Chem.50, 6072-6077 (2002). Abstract

Review

Chu , K.K. et al. Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values. J. Clin. Pharmacol. 42, 976-984 (2002). Abstract

2001

In vitro

	Hsieh, T.C. et al. Cell growth and gene modulatory activities of Yunzhi (Winsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells. Int. J. Oncol.18, 81-88 (2001). *** Abstract
	Mao, X.W. et al. Evaluation of polysaccharopeptide effects against C6 glioma in combination with radiation. Oncology61, 243-246 (2001). *** Abstract

2000

Review

	Kidd, P.M. The use of mushroom glucans and proteoglycans in cancer treatment. Altern. Med. Rev.5, 4-27 (2000). *** Full PDF Article
	Ooi, V.E. et al. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr. Med. Chem.7, 715-729 (2000). Abstract

1999

In vitro

Kim, H.S. et al. In vitro chemopreventative effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis20, 1637-1640 (1999). Abstract

1998

Animal

Wu, D. et al. Dietary supplementation with mushroom-derived protein-bound glucan does not enhance immune function in young and old mice. J. Nutr.128, 193-197 (1998). Abstract

Review

	Ng, T.B. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus veriscolor (Basidiomycetes: polyporaceae). Gen. Pharmac.30, 1-4 (1998). *** Abstract
	Gong, S. et al. Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides. Acta Pharmacol. Sin.19, 67-70 (1998). *** Abstract

1997

Animal

	Ng, T.B. et al. Polysaccharopeptide from the mushroom Coriolus versicolor possesses analgesic activity but does not produce adverse effects on female reproductive or embryonic development in mice. Gen. Pharmacol.29, 269-273 (1997). *** Abstract
	Qian, Z.M. et al. Polysaccharide peptide (PSP) restores immunosuppression induced by cyclophosphamide in rats. Am. J. Chin. Med.25, 27-35 (1997). *** Abstract

In vitro

	Collins, R.A. et al. Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection. Life Sci.60, 383-387 (1997). *** Abstract
	Dong, Y. et al. In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs. Life Sci.60, 135-140 (1997). *** Abstract

1996

Animal

Wang, H.X. et al. Polysaccharide-peptide complexes from the cultured mycelia of the mushroom coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages. Int. J. Biochem. Cell Biol.28, 601-607 (1996). *** Abstract

In vitro